Fritjof Helmchen

Professor, Departement of Neurophysiology
Director, Laboratory of Neural Circuit Dynamics

Helmchen is characterizing the properties of individual neurons in vivo and investigate how synaptic inputs are integrated in their dendrites to eventually cause action potentials that are transmitted to target neurons. Using in vivo electrophysiology and 2-photon imaging we perform both intracellular recordings from individual neurons as well as optical measurements of population activity. Development of 2-photon microscopy techniques for high-resolution imaging in living and behaving rodents.

Richard Kramer

Associate Professor of Neurobiology
Director, Kramer Lab

Kramer uses a combination of optical, electrophysiological, and molecular methods to study ion channels, the proteins that generate electrical signals, and synaptic transmission, the process that allows a neuron to communicate chemically with other cells. Many of our most recent studies utilize novel chemical reagents, designed to manipulate or monitor the function of ion channels and synapses. Current Project: Optical studies of synaptic transmission in the retina.

Mark J Schnitzer

Associate Professor of Biology and Applied Physics, Stanford
HHMI Investigator
Principal Investigator, Schnizer Group

Dr. Schnitzer has longstanding interests in neural circuit dynamics and optical imaging focusing on: the development and application of fiber-optic, micro-optic, and nanophotonic imaging techniques for studies of learning and memory; in vivo fluorescence imaging and behavioral studies of hippocampal-dependent cognition and learning; and development of high-throughput, massively parallel imaging techniques for studying brain function in Drosophila.

Serge Picaud

Head of the Department of Visual Information Processing. Vision Institute

The goal of Serge Picaud’s three-dimensional holography research is to enable Neuroscientists to manipulate neural circuits in order to discover how patterns of activity relate to sensation, perception and cognition. This capability is essential for discovering how communication between neurons gives rise to healthy brain function. These insights will improve our ability to identify effective targets and methods for treating neurological diseases and disorders.

Vincent Allen Pieribone

Professor of Cellular and Molecular Physiology and of Neurobiology
Fellow, John B. Pierce Laboratory

Dr Pieribone is developing genetically encoded fluorescent probes of membrane electrical potential. These probes allow one to use optical instruments (microscopes) to monitor the electrical activity of neurons. He has also engineered miniature imaging systems that can be head mounted on mammels and allow mobile recording of neuronal activity.

Chris Xu

Professor and Director of Undergraduate Studies, Dept. of Applied and Engineering Physics, Cornell University
Director, Xu Research Group

Xu’s research has two main thrusts: biomedical imaging and fiber optics. He is exploring new concepts and techniques for in vivo imaging deep into scattering biological specimens, such as mouse brain; developing new medical endoscopes for non-invasive real-time diagnostics of tissues without any exogenous contrast agent and novel optical fibers and fiber-based devices for biomedical imaging and optical communications.

Elly Nedivi

Professor of Brain & Cognitive Sciences and Biology, MIT Neuroscience
Principal Investigator, Nedivi Lab

The Nedivi lab, part of the Picower Institute for Learning and Memory, studies the cellular mechanisms that underlie activity-dependent plasticity in the developing and adult brain through studies of neuronal structural dynamics, identification of the participating genes, and characterization of the proteins they encode.

Baldwin Goodell

Principal Investigator: Gray Matter Research

Goodell and his company GrayMatter Research focuses on Microdrive Systems and Recording Chamber Systems. For the BRAIN Initiative, Goodell and his colleagues aim to develop optrodes, which are implantable columns of lights and wires for simultaneous electrical recording of neurons and delivery of light flashes to multiple brain areas.

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