Synthetic Neurobiology Group

MIT Neuroscience
Principal Investigator: Ed Boyden, Ph.D.

The Synthetic Neurobiology Group develops tools that enable the mapping of the molecules and wiring of the brain, the recording and control of its neural dynamics, and the repair of its dysfunction.The Group applies these to the systematic analysis of brain computations, aiming to reveal the fundamental mechanisms of brain function, and yielding new, ground-truth therapeutic strategies for neurological and psychiatric disorders.

Optogenetics: molecules enabling neural control by light. From SBG website.

Optogenetics: molecules enabling neural control by light. From SBG website.

Web Information


Contact Information


Phone:  (617) 324-3085

Address: Building E15: E15-421| 20 Ames St.| Cambridge, MA 02139


Ultra-Multiplexed Nanoscale In Situ Proteomics for Understanding Synapse Types

Tools for Cells and Circuits (RFA MH-14-216)
Edwards S. Boyden, Director of the Synthetic Neurobiology Group, Massachusetts Institute of Technology

Dr. Boyden’s team will simultaneously image both the identities and locations of multiple proteins within individual synapses – made possible by a new technique called DNA-PAINT.

2015-03-25 11.56.49 am

DNA-PAINT super-resolution image of microtubules inside a fixed HeLa cell using Atto 655–labeled imager strands (10,000 frames, 10-Hz frame rate). Inset, labeling and imaging schematic for DNA-PAINT in a cellular environment. From Neuron doi:10.1038/nmeth.2835


From Website

Tools for mapping the molecular structure of the brain

Tools for recording high-speed brain dynamics

Optogenetics: molecules enabling neural control by light

Optogenetics: hardware enabling neural control by light

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