Sestan Lab

Principal Investigator: Nenad Sestan
Yale Neuroscience

The Sestan Lab’s research centers on understanding the molecular and cellular basis of how neurons acquire distinct identities and form proper synaptic connections in the cerebral cortex, a part of the brain that is critical for cognition, perception and behavior. The Lab also studies how these complex developmental processes have evolved and become compromised in human disorders, such as autism. An important element of our research is the integration of complementary approaches.

Center of Regeneration Medicine and Stem Cell Research

Director: Arnold Kriegstein
UCSF Neuroscience

The Center’s organization is designed to foster collaborations derived from work on different organs and tissue systems. Accordingly, the laboratories and research efforts are organized along a series of pipelines, each focusing on a particular tissue or organ system, and including basic research as well as translational research directed toward clinical applications. A basic researcher and a clinician direct each pipeline

Scanziani Lab

Principal Investigator: Massimo Scanziani
UC San Diego’s Neuroscience

The goal of Scanziani Lab’s research is to understand the mechanisms by which elementary circuits of neurons control the spatial and temporal structure of cortical activity. Towards this goal they use in vivo and in vitro electrophysiological, imaging and anatomical techniques as well as behavioral approaches. Their model system is the rodent’s sensory cortex.

Geschwind Lab

Principal Investigator: Daniel H Geschwind
UCLA Neuroscience

The Geschwind laboratory is dedicated to improve treatment and understanding of neurodevelopmental and neurodegenerative conditions, focusing on autism spectrum disorders, dementia, neural repair, and inherited ataxia. The lab leverages the fields of genetics and genomics, coupled with basic neurobiology, to obtain a systems level understanding of disease. The lab has pioneered the application of gene expression and network methods in neurologic and psychiatric disease.

Ecker Lab

Principal Investigator: Joseph R Ecker
Salk Institute for Biological Studies

Being able to study the epigenome in great detail and in its entirety will provide a better understanding of plant productivity and stress resistance, the dynamics of the human genome, stem cells’ capacity to self-renew and how epigenetic factors contribute to the development of tumors and disease. We are now exploring how DNA methylation effects the development of human embryonic stem (hES) cells as well as induced pluripotent stem (IPS) cells as they are induced to differentiate into other types of cells.

Sanes Lab

Principal Investigator: Joshua R Sanes
Neuroscience@Harvard

The Sanes Lab wants to learn how neural circuits are assembled in young animals and how they process information in adults. A particular focus is identification and analysis of synaptic recognition molecules responsible for the amazing specificity of connections that underlies complex neural processing. We use a combination of genetic, molecular, histological and electrophysiological approaches to address these issues. Our main model system is the mouse retina.

Osten Lab

Principal Investigator: Pavel Osten
Cold Spring Harbor Laboratory

Osten’s lab works on identification and analysis of brain regions, neural circuits, and connectivity pathways that are disrupted in genetic mouse models of autism and schizophrenia. Osten and colleagues have developed the first systematic approach to the study of neural circuits in mouse models of psychiatric diseases, based on a pipeline of anatomical and functional methods for analysis of mouse brain circuits employing serial two-photon (STP) tomography.

Nelson Lab

Principal Investigator: Sacha B. Nelson
Brandeis University

Despite their functional and clinical importance, the cell types that comprise the neocortex and the molecular mechanisms that specify their properties and connectivity are only partly understood. Nelson Lab studies the development and function of the neocortex in the laboratory mouse using a combination of genetic, genomic and electrophysiological approaches.

Ngai Lab

Helen Wills Neuroscience Institute
Director, John Ngai

The Ngai Lab focuses on the molecular mechanisms underlying the development and function of the vertebrate olfactory system using molecular, genomic, computational and behavioral approaches. The Ngai Lab is also leveraging high-throughput genomic and genome engineering techniques. Ngai Lab aims to make significant discoveries on the molecules, cells and circuits underlying the development, regeneration and function of the nervous system during normal processes and disease.

Allen Brain Atlases

The Allen Mouse and Human Brain Atlases are projects within the Allen Institute for Brain Science which seek to combine genomics with neuroanatomy by creating gene expression maps for the mouse and human brain.

Seven brain atlases have been published: Mouse Brain Atlas, Human Brain Atlas, Developing Mouse Brain Atlas, Developing Human Brain Atlas, Mouse Connectivity Atlas, Non-Human Primate Atlas, and Mouse Spinal Cord Atlas. The atlases are free and available for public use online

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