Circuitry Underlying Memory replay

Principal Investigator: Ivan Soltesz
UC Irvine Neuroscience

Title: “Towards a Complete Description of the Circuitry Underlying Memory replay”
BRAIN Category: Understanding Neural Circuits (RFA NS-14-009)

Dr. Soltesz’s team will combine computer brain modeling and large-scale recordings of hundreds of neurons to understand how the brain generates sharp-wave-ripples, a neuronal activity pattern essential for learning and memory.

NIH Webpages

How GABAergic interneurons in the hippocampus choose their postsynaptic partners

How GABAergic interneurons in the hippocampus choose their postsynaptic partners

Project Description

The function of a brain region is an emergent property of many cell types. The criteria needed to understand a network have been established in studies of invertebrate “simple” networks, but there has not yet been an attempt to provide such a full, mechanistic understanding of any network in the vertebrate brain. We believe that the time is now ripe for such an effort. Specifically, we propose to understand how the CA3 network in the hippocampus generates sharp-wave-ripples (SWR). These events are of great interest because of their cognitive function: they represent replay of episodic memory sequences and are required for subsequent memory recall, as demonstrated at the behavioral level. Our efforts to understand the SWR will build on previous work establishing the cell types of the hippocampus. However, to meet the criteria for “understanding”, a great deal of additional information about connectivity and intrinsic properties of cells must be obtained. We will use recently developed large-scale electrical and optical recording methods and ontogenetic to obtain this information. In addition, several new methods/tools will be developed. Notably, we propose to optimize a novel synapse localization optical method to obtain high-throughput cell type-specific information about the connective of the CA3 network. We will also construct the first full-scale computational model of the CA3 region of the hippocampus, in which every cell and synaptic connection is explicitly represented. This strictly data-driven, full-scale model will provide a widely applicable tool for synthesizing experimental results and testing our ability to understand the principles that underlie SWR generation.

Public Health Relevance Statement

We propose to make the first attempt to fully understand a cognitively important event, called memory replay, in terms of the detailed properties of the brain cells involved. We will use cutting-edge large-scale recording technologies to study and manipulate identified cell types, and develop a novel method that will provide needed information about the connectivity between the neurons involved. Finally, we will construct the first full- scale computational of model of the brain area that produces the memory replay in which every cell is explicitly simulated. These powerful new approaches are likely to yield major insights into the principles by which the interactions of neurons gives rise to cognitive function, with important implications for memory disorders.

NIH Spending Category

Bioengineering; Mental Health; Neurosciences

Project Terms

Area; arm; base; Behavioral; Brain; brain cell; Brain region; cell type; Cells; cognitive function; Computer Simulation; Data; dentate gyrus; Detection; entorhinal cortex; Episodic memory; Event; Generations; Hippocampus (Brain); Image; in vivo; insight; interest; Interneurons; Invertebrates; Measurement; Measures; Medial; Mediating; meetings; Memory; Memory Disorders; memory recall; Methods; Modeling; Neurons; novel; novel strategies; optic imaging; Optical Methods; Optics; optogenetics; Pattern; Process; Property; public health relevance; Pyramidal Cells; Radial; reconstitution; Recurrence; research study; Role; Running; Simulate; supercomputer; Synapses; System; Technology; Test Result; Testing; Time; tool; Transfection; Work

No Comments » for Circuitry Underlying Memory replay
4 Pings/Trackbacks for "Circuitry Underlying Memory replay"
  1. […] Webpage: anatomy.uci.edu/soltesz.html UC Irvine Neuroscience Brain Initiative Grant […]

  2. […] Website:  ivansolteszlab.org/ Brain Initiative Grant […]

  3. […] Department of Anatomy & Neurobiology Website: anatomy.uci.edu/ Department of Neurobiology and Behavior:  neurobiology.uci.edu/ Brain Initiative Grant […]

  4. […] Department of Anatomy & Neurobiology Website:  anatomy.uci.edu/ Department of Neurobiology and Behavior website: neurobiology.uci.edu/ Brain Initiative Grant […]

Leave a Reply

Skip to toolbar