Allen Cell Types Database

The Allen Institute for Brain Science is taking the first major scientific step to create a searchable standards database for the brain with the launch of the Allen Cell Types Database.

The first release includes information on just 240 neurons out of hundreds of thousands in the mouse visual cortex, with a focus on the electrophysiology of those individual cells: the electrical pulses that tell a neuron to fire, initiating a pattern of neural activation that results in perception and action.

Rapid imaging of a living brain

Using a new high-speed, high-resolution imaging method, researchers at Washington University were able to see blood flow, blood oxygenation, oxygen metabolism, and other functions inside a living mouse brain at faster rates than ever before.

The new method is called “photoacoustic microscopy” (PAM), a single-wavelength, pulse-width-based technique developed by Lihong Wang, PhD, the Gene K. Beare Professor of Biomedical Engineering in the School of Engineering & Applied Science, and his team.

Articles on the BRAIN Initiative Spring 2015

The $5 Billion Race to Map Your Brain
Ozy April 29. 2015 by Chana Schoenberger

Obama’s BRAIN Initiative yields first study results
Reuters April 30, 2015 by Sharon Begley

Walter Koroshetz – Early Days of the NIH BRAIN initiative

Walter Koroshetz presentation at Neuroscience BioConference Live [online] conference on Mar 19, 2015.

From Labroots synopsis: “The major funded efforts at this time fit into 3 main categories; 1) defining the components of brain circuits, i.e., a cell census; 2) developing and testing tools for recording high density information on circuit structure, activity, and manipulating circuit activity; 3) novel technology for noninvasive interrogation and manipulation of circuit activity (next generation imaging).”

BRAIN Initiative Workshop: Early Access to Neuromodulation and Recording- 6/3-6/4

TITLE: NIH BRAIN Initiative Workshop: Industry Partnerships to Facilitate Early Access to Neuromodulation and Recording Devices for Human Clinical Studies

TIME: 12:00:00 PM DATE: June 3 and 4, 2015

PLACE: Neuroscience Center Building (NSC)

Live NIH Videocast (archived after seminar)

NeuroElectro.org – Wikipedia for Neurons

To help scientists make sense of this “brain big data,” researchers at Carnegie Mellon University have used data mining to create www.neuroelectro.org, a publicly available website that acts like Wikipedia, indexing physiological information about neurons.

The site will help to accelerate the advance of neuroscience research by providing a centralized resource for collecting and comparing data on neuronal function.

Brain Mapping Overview

Brain mapping is a set of neuroscience techniques predicated on the mapping of (biological) quantities or properties onto spatial representations of the (human or non-human) brain resulting in maps.

Brain mapping is further defined as the study of the anatomy and function of the brain and spinal cord through the use of imaging (including intra-operative, microscopic, endoscopic and multi-modality imaging), immunohistochemistry, molecular & optogenetics, stem cell and cellular biology, engineering (material, electrical and biomedical), neurophysiology and nanotechnology.

White House Conference on BRAIN Initiative

On September 30, 2014, the White House announced new investments in the Obama Administration’s BRAIN initiative – a bold, new initiative focused on revolutionizing our understanding of the human brain.

John Holdren, Director of the Office of Science & Technology, gave the keynote introduction of the BRAIN Initiative. Meredith Drosback, who works in the OSTP science division, coordinated the conference panelists. Paul Alivisatos, Director of the Lawrence Berkeley National Laboratory moderated two panels (starting at minute 16).

Kavli video on the BRAIN Initiative

The Kavli Foundation has made possible an inspiring five minute video on the BRAIN Initiative. This video was produced by The Science Network in collaboration with Science Visualization.

Kavli Foundation sponsored numerous symposiums and informal meetings in 2011 through 2013 that developed the initial concept for the BRAIN Inititative. Over 100 neuroscientists participated in these meetings which resulted in the Brain Activity Map Project proposal that “would prove important to the scientific thinking behind the BRAIN Initiative, as well as a major catalyst for its launching.”

BRAIN Initiative Overview

The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is aimed at revolutionizing our understanding of the human brain.

The BRAIN Initiative will accelerate the development and application of new technologies to produce dynamic pictures of the brain that show how individual brain cells and complex neural circuits interact at the speed of thought. These technologies will open new doors to explore how the brain encodes, stores, and retrieves vast quantities of information, and shed light on the complex links between brain function and behavior

  • Eric Betzig

    Physicist and neuroscientist based at the Janelia Research Campus. Awarded the 2014 Nobel Prize in Chemistry for “the development of super-resolved fluorescence microscopy”.

    Eric Betzig develops novel optical imaging tools in an effort to open new windows into molecular, cellular, and neurobiology. Betzig is focusing on improvements in five areas: Spatial Resolution, Temporal Resolution, Labeling Technology, Deep-Tissue Imaging, and Noninvasive, Data-Rich Imaging.

  • BRAIN Initiative Overview

    The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is aimed at revolutionizing our understanding of the human brain.

    The BRAIN Initiative will accelerate the development and application of new technologies to produce dynamic pictures of the brain that show how individual brain cells and complex neural circuits interact at the speed of thought. These technologies will open new doors to explore how the brain encodes, stores, and retrieves vast quantities of information, and shed light on the complex links between brain function and behavior

  • 2014 BRAIN Initiative Awards

    NIH announced its initial $46 million investment for the BRAIN Initiative reseach on September 30, 2014.

    These projects lay the groundwork for visualizing the brain in action. More than 100 investigators in 15 states and several countries will work to develop new tools and technologies to understand neural circuit function and capture a dynamic view of the brain in action.

    Funding opportunites for fiscal year 2016 were announced on Janurary 13, 2015.

  • BRAIN Multi-Council Working Group

    On Wednesday, March 4, 2015, the BRAIN Multi-Council Working Group met at the Neuroscience Center Building.

    The meeting agenda included discussion of BRAIN research supported by NIH, neuroethics, and presentations on BRAIN-related activities supported by the four additional Federal agencies involved in The BRAIN Initiative: DARPA, NSF, the FDA, and IARPA.

    The meeting was open to the public and videocast can be accessed from this post.

  • NIH Institutes and BRAIN Initiative

    National Eye Institute
    National Institute on Aging
    National Institute on Alcohol Abuse and Alcoholism
    National Institute of Biomedical Imaging and Bioengineering
    National Institute of Child Health and Human Development
    National Institute on Deafness and Other Communication Disorders
    National Institute on Drug Abuse
    National Institute of Mental Health
    National Institute of Neurological Disorders and Stroke
    National Center for Complementary and Integrative Health

  • Affiliated Partners & The BRAIN Initiative

    In addition to the National Institute of Health’s 10 Institutes and other programs spearheading the BRAIN Initiative, numerous other Federal agencies, companies, universities, private research centers, and universities are participating.

    Over $300 million has been pledged to support the BRAIN Initiative. The five participating federal agencies are NIH, NSF, DARPA, FDA and IARPA. Major non-governmental commitments have come from numerous participants including the original private sector partners – Allen Institute, HHMI, and Kavli Foundation.

  • 2014 Chemistry Nobel Prize

    “The Nobel Prize in Chemistry 2014 was awarded jointly to Eric Betzig, Stefan W. Hell and William E. Moerner “for the development of super-resolved fluorescence microscopy”.

    For a long time optical microscopy was held back by a presumed limitation: that it would never obtain a better resolution than half the wavelength of light. Helped by fluorescent molecules the Nobel Laureates in Chemistry 2014 ingeniously circumvented this limitation. “Their ground-breaking work has brought optical microscopy into the nanodimension”, Nobel committee……

  • BRAIN Initiative Workshop: Early Access to Neuromodulation and Recording- 6/3-6/4

    TITLE: NIH BRAIN Initiative Workshop: Industry Partnerships to Facilitate Early Access to Neuromodulation and Recording Devices for Human Clinical Studies

    TIME: 12:00:00 PM DATE: June 3 and 4, 2015

    PLACE: Neuroscience Center Building (NSC)

    Live NIH Videocast (archived after seminar)

  • NIH Neuroscience Seminar- June 1, 2015

    TITLE: Rethinking Depression and its Treatment: Perspectives from Studies of Deep Brain Stimulation

    AUTHOR: Helen Mayberg, M.D., Emory University

    TIME: 12:00:00 PM DATE: Monday, June 1, 2015

    PLACE: Porter Neuroscience Research Center

    Live NIH Videocast (archived after seminar)

  • NIH Neuroscience Seminar- June 8, 2015

    TITLE: What goes out must come in: coupling of synaptic exo- and endocytosis

    AUTHOR: Jurgen Klingauf, Ph.D.

    TIME: 12:00:00 PM DATE: Monday,June 8, 2015

    PLACE: Porter Neuroscience Research Center

    Live NIH Videocast (archived after seminar)

  • NIH Neuroscience Seminar- June 15, 2015

    TITLE: Photo-control of endogenous ion channels and neurotransmitter receptors in the CNS

    AUTHOR: Richard Kramer, Ph.D., University of California, Berkeley

    TIME: 12:00:00 PM DATE: Monday, June 15, 2015

    PLACE: Porter Neuroscience Research Center

    Live NIH Videocast (archived after seminar)

  • BRAIN 2015 Weekly Hangout on Air

    AIR DATE: Starting Late Summer 2015

    TOPICS FOR DISCUSSION
    I- BRAIN Initiative Website
    II- Neuromodulation & Control Workshop

    MODERATOR: TBD

    FEATURED GUEST: TBD

    INVITED PARTICIPANTS: TBD

@BrainMapping onAir Tweets

  • BRAIN 2015 Digest – 3/16 to 3/20

    The focus for the week of 3/16 to 3/20/15 was on creating posts for each BRAIN Initiative September 2014 grant.

    We also assembled posts that compiled all the grants within the following categories:
    Census of Cell Type
    Tools for Cells and Circuits
    Next Generation Human Imaging
    Large-Scale Recording-Modulation – New Technologies
    Large-Scale Recording-Modulation – Optimization
    Understanding Neural Circuits

  • BRAIN 2015 Digest – 3/9 to 3/13/15

    The focus for this week was on curating high level overview posts of The BRAIN Initiative.

    Posts include
    BRAIN Initiative Overview
    Advisory Committee to Director
    BRAIN Awards and New Funding Opportunities
    NIH Institutes and The BRAIN Initiative
    BRAIN Multi-Council Working Group
    BRAIN participants beyond NIH

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