Principal Investigator: Bryan Roth
Roth Lab studies the structure and function of G-Protein coupled receptors (GPCRs). Roth Lab is part of the Department of Pharmacology, a research department in the School of Medicine at the University of North Carolina at Chapel Hill. The Roth lab is the principal contractor for the NIMH Psychoactive Drug Screening Program which includes the PDSP Ki database.
Serotonin receptor neurobiology: Since 1984, my lab has studied serotonin (5-hydroxytryptamine; 5-HT) and its receptors. Recently we have been focused on targeting and trafficking of 5-HT2-family receptors . Ongoing projects are directed to using mouse genetics to delineate the roles of accessory proteins and post-translational modifications in 5-HT receptor actions.
BRAIN Initiative Grant – ” Dreadd2.0: An Enhanced Chemogenetic Toolkit”
Address: 4072 Genetic Medicine
UNC-CH School of Medicine
Chapel Hill, NC 27599-7365